Ozone Therapy for Pets: The Complete Evidence-Based Guide

A research-grade resource for pet owners and referring veterinarians researching medical ozone therapy for dogs and cats. Reviewed by Dr. Susset Diaz Castillo, DVM, PhD, a Florida-licensed mobile veterinarian trained in integrative and biologic optimization medicine.

What this guide covers

  • What medical ozone is, and how it differs from atmospheric ozone
  • A brief history — from human medicine to veterinary adoption
  • Mechanism of action: oxidative hormesis, immune modulation, mitochondrial support, antimicrobial action, tissue regeneration
  • Six administration routes used in pets — rectal insufflation, subcutaneous, major autohemotherapy, topical ozonated oils, ozonated saline, intra-articular
  • Evidence-stratified indications — strong evidence (dentistry, wound healing), emerging evidence (osteoarthritis, IBD, chronic ear infections), adjunctive support (CKD, cancer palliation)
  • Safety profile and explicit contraindications (G6PD deficiency, hyperthyroid crisis, active internal bleeding)
  • What ozone therapy is NOT — it does not cure cancer, replace antibiotics, or substitute for emergency care
  • What a typical 6–10 session treatment course looks like
  • How to choose a qualified veterinary ozone practitioner
  • 16 cited peer-reviewed references

VestaSoul My Vet At Home® offers in-home ozone therapy consultations throughout Miami-Dade County. Book online at myvetathomemobilevet.com or call (786) 516-4731. Mon–Fri, 9am–5pm.