Ozone Therapy for Pets: The Complete Evidence-Based Guide

A research-grade resource for pet owners and referring veterinarians researching medical ozone therapy for dogs and cats. Reviewed by Dr. Susset Diaz Castillo, DVM, PhD, a Florida-licensed mobile veterinarian trained in integrative and biologic optimization medicine.

What this guide covers

  • What medical ozone is, and how it differs from atmospheric ozone
  • A brief history — from human medicine to veterinary adoption
  • Mechanism of action: oxidative hormesis, immune modulation, mitochondrial support, antimicrobial action, tissue regeneration
  • Six administration routes used in pets — rectal insufflation, subcutaneous, major autohemotherapy, topical ozonated oils, ozonated saline, intra-articular
  • Evidence-stratified indications — strong evidence (dentistry, wound healing), emerging evidence (osteoarthritis, IBD, chronic ear infections), adjunctive support (CKD, cancer palliation)
  • Safety profile and explicit contraindications (G6PD deficiency, hyperthyroid crisis, active internal bleeding)
  • What ozone therapy is NOT — it does not cure cancer, replace antibiotics, or substitute for emergency care
  • What a typical 6–10 session treatment course looks like
  • How to choose a qualified veterinary ozone practitioner
  • 16 cited peer-reviewed references

VestaSoul My Vet At Home® offers in-home ozone therapy in select areas of Miami-Dade County and Broward ZIP codes 33021 and 33312. Ozone is a doctor-recommended service, not a treatment you book on its own — care begins with an All-Included Visit, where Dr. Diaz performs a comprehensive evaluation and recommends ozone therapy as part of a personalized treatment plan when it's the right fit. Book an All-Included Visit securely online — for questions, call (786) 516-4731. Book online to check your ZIP and current appointment openings.

VestaSoul — My Vet At Home® is a mobile veterinary house-call practice serving select Miami-Dade and Broward ZIP codes.